ODM cov khaub ncaws zoo rau cov khaub ncaws - Hoobkas muab rau cov ris tsho ntiag tug

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Paub meej

Cov fungi yog qhov zoo tshaj plaws rau ntau yam ntawm cov khoom hnyav-molecular- hnyav polysaccharide uas lawv tsim, thiab bioactive polyglycans muaj nyob rau hauv txhua qhov ntawm cov nceb. Polysaccharides sawv cev rau ntau hom kab mob lom neeg macromolecules nrog ntau yam physiochemical zog. Ntau yam polysaccharides tau muab rho tawm los ntawm cov txiv hmab txiv ntoo lub cev, spores, thiab mycelia ntawm lingzhi; lawv yog tsim los ntawm fungal mycelia kab lis kev cai nyob rau hauv fermenters thiab muaj peev xwm txawv nyob rau hauv lawv cov qab zib thiab peptide compositions thiab molecular hnyav (piv txwv li, ganoderans A, B, thiab C). G. lucidum polysaccharides (GL-PSs) tau tshaj tawm los nthuav tawm ntau yam ntawm bioactivities. Polysaccharides feem ntau tau txais los ntawm cov nceb los ntawm kev rho tawm nrog dej kub ua raws li los ntawm nag lossis daus nrog ethanol lossis membrane sib cais.

Kev txheeb xyuas cov qauv ntawm GL-PSs qhia tias cov piam thaj yog lawv cov piam thaj tseem ceeb. Txawm li cas los xij, GL-PSs yog heteropolymers thiab tuaj yeem muaj xylose, mannose, galactose, thiab fucose hauv kev sib txawv, suav nrog 1-3, 1-4, thiab 1-6-txuas β thiab α-D (lossis L)-substitutions .

Branching conformation thiab solubility yam ntxwv tau hais tias yuav cuam tshuam rau cov khoom antitumorigic ntawm cov polysaccharides. Cov nceb kuj muaj cov matrix ntawm polysaccharide chitin, uas yog indigestible heev los ntawm tib neeg lub cev thiab yog ib feem lub luag hauj lwm rau lub cev hardness ntawm nceb. Ntau cov tshuaj ua kom zoo dua polysaccharide uas tau muab rho tawm los ntawm G. lucidum tam sim no tau muag hauv khw muag khoom.

Terpenes yog ib chav kawm ntawm cov khoom sib xyaw ua ke uas nws cov pob txha pob txha muaj ib lossis ntau dua isoprene C5 units. Piv txwv ntawm terpenes yog menthol (monoterpene) thiab β-carotene (tetraterpene). Ntau yam yog alkenes, txawm tias qee qhov muaj lwm pab pawg ua haujlwm, thiab ntau yam yog cyclic.

Triterpenes yog subclass ntawm terpenes thiab muaj lub cev pob txha ntawm C30. Feem ntau, triterpenoids muaj molecular hnyav li ntawm 400 mus rau 600 kDa thiab lawv cov qauv tshuaj yog complex thiab oxidized heev.

Hauv G. lucidum, cov qauv tshuaj ntawm cov triterpenes yog raws li lanostane, uas yog ib qho metabolite ntawm lanosterol, biosynthesis ntawm uas yog raws li cyclization ntawm squalene. Extraction ntawm triterpenes feem ntau yog ua los ntawm ethanol solvents. Cov extracts tuaj yeem ua kom huv ntxiv los ntawm ntau txoj kev sib cais, suav nrog HPLC li qub thiab rov qab-theem.

Thawj triterpenes cais los ntawm G. lucidum yog ganoderic acids A thiab B, uas tau txheeb xyuas los ntawm Kubota li al. (1982). Txij thaum ntawd los, ntau tshaj 100 triterpenes uas paub cov tshuaj muaj pes tsawg leeg thiab cov qauv molecular tau tshaj tawm tias tshwm sim hauv G. lucidum. Ntawm lawv, ntau dua 50 tau pom tias yog qhov tshiab thiab tshwj xeeb rau cov kab mob no. Feem ntau yog ganoderic thiab lucidenic acids, tab sis lwm yam triterpenes xws li ganoderals, ganoderiols, thiab ganodermic acids kuj tau txheeb xyuas (Nishitoba li al. 1984; Sato li al. 1986; Budavari 1989; Gonzalez 9et 9. 2002; Akihisa et al. 2007;

G. lucidum yog kom meej meej nplua nuj nyob rau hauv triterpenes, thiab nws yog cov chav kawm ntawm cov tebchaw uas muab cov tshuaj ntsuab nws iab saj thiab, nws ntseeg, confers on nws ntau yam kev noj qab haus huv cov kev pab cuam, xws li lipid-txo thiab dant teebmeem. Txawm li cas los xij, cov ntsiab lus triterpene sib txawv hauv qhov sib txawv thiab cov theem ntawm cov nceb. Cov profile ntawm cov triterpenes sib txawv hauv G. lucidum tuaj yeem siv los ua kom paub qhov txawv ntawm cov kab mob no los ntawm lwm hom kab mob taxonomically, thiab tuaj yeem ua pov thawj rau kev faib tawm. Cov ntsiab lus triterpene kuj tuaj yeem siv los ntsuas qhov zoo ntawm cov qauv ganoderma sib txawv